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​Our Grantees

A scientist wearing blue gloves and a lab coat looks into a microscope, adjusting the slide with one hand in a brightly lit laboratory setting.
Logo for SACYL Pharmaceuticals, with SACYL in bold blue gradient letters, PHARMACEUTICALS below in smaller blue text, and six stylized N shapes in different colors on the right.

Sacyl Pharmaceuticals

$100,000
Awarded January 2023

New York, NY

About

Sacyl Pharmaceuticals, Inc. is working towards innovative contraceptive solutions, leveraging the genetically and pharmacologically validated contraceptive target soluble adenylyl cyclase (sAC; ADCY10) into on-demand options for men.

Our Grant

MCI’s support facilitates the development of novel sAC inhibitors as on-demand contraceptives for men by optimizing the safety and efficacy of new compounds. These steps are crucial to overcome the high bar that will be required of any new contraceptive product.

Press Releases

Male Contraceptive Initiative Provides Funding Support to Sacyl Pharmaceuticals, Inc. for Developing an On-Demand Male Contraceptive
March 4, 2024

Sacyl Pharmaceuticals: Pioneering On-Demand Male Contraception with sAC Inhibitors

Publications

Miller, M., Rossetti, T., Ferreira, J., Ghanem, L., Balbach, M., Kaur, N., Levin, L. R., Buck, J., Kehr, M., Coquille, S., van den Heuvel, J., Steegborn, C., Fushimi, M., Finkin-Groner, E., Myers, R. W., Kargman, S., Liverton, N. J., Huggins, D. J., & Meinke, P. T. (2022). Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. Journal of medicinal chemistry, 65(22), 15208–15226. https://doi.org/10.1021/acs.jmedchem.2c01133

Rossetti, T., Ferreira, J., Ghanem, L., Buck, H., Steegborn, C., Myers, R. W., Meinke, P. T., Levin, L. R., & Buck, J. (2022). Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology, 13, 1013845. https://doi.org/10.3389/fphys.2022.1013845

Sacyl Pharmaceuticals In the News:

Meet MCI's Grantees & Fellows!

Our grantees and fellows represent some of the finest minds in the male contraception research community from around the world.

​At Male Contraceptive Initiative, we prioritize funding research that aligns with our mission of driving male contraception closer to clinical trials. We strategically allocate our resources to support a diverse range of projects, focusing on non-hormonal and reversible methods that have the potential to meet the needs of a broader population. Our goal is to catalyze progress in this field and bring innovative male birth control options to market.

Discover the innovative research being conducted by our grantees and fellows by clicking on the buttons below:

MCI'S GRANTEES
MCI'S FELLOWS

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Welcome to your comprehensive resource on the future of male contraception! We have packed this site with vital information, and to help you find exactly what you need, we’ve created a detailed guide. Please use the Table of Contents on our homepage to easily navigate to the research, news, or resources that interest you most. This will ensure you can explore all of our important content with ease. You can access the Table of Contents by clicking on the button below:

TABLE OF CONTENTS
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