Deborah Anderson,
Professor $150,000 / 2 Years Awarded January 2023 |
Deborah Anderson, PhDBoston University
Boston, Massachusetts About
Dr. Deborah Anderson is a Professor of Medicine at Boston University. Using a novel sperm-binding antibody, she and her team are engineering novel non-hormonal contraceptives for men and women alike. Our Grant
Our support of Dr. Anderson’s work utilizes their Human Contraceptive Antibody (HCA) and incorporates it into lubricants and bioadhesive polymers as a male or couples’ method of contraception. As a part of the work, compatibility, stability, and functional activity of the antibody will be tested using a simulated model. The antibody is concurrently being developed in a vaginal film and tested in first-in-human studies. |
Dr. Deborah Anderson: Pioneering Non-Hormonal Contraception with Human Contraceptive Antibody (HCA)
Publications
Baldeon-Vaca, G., Marathe, J. G., Politch, J. A., Mausser, E., Pudney, J., Doud, J., Nador, E., Zeitlin, L., Pauly, M., Moench, T. R., Brennan, M., Whaley, K. J., & Anderson, D. J. (2021). Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women. EBioMedicine, 69, 103478. https://doi.org/10.1016/j.ebiom.2021.103478
Deborah J. Anderson, Daniel S. Johnston, A brief history and future prospects of contraception. Science380,154-158(2023).DOI:10.1126/science.adf9341
Nador E, Mausser E, Marathe JG, Politch JA, Thurman AR, Whaley KJ, Anderson DJ. Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film. Fertil Steril. 2024 Oct 22:S0015-0282(24)02320-3. doi: 10.1016/j.fertnstert.2024.10.026. Epub ahead of print. PMID: 39447830.
Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel). 2024 Mar 6;13(1):17. doi: 10.3390/antib13010017. PMID: 38534207; PMCID: PMC10967333.
Dohadwala S, Geib MT, Politch JA, Anderson DJ. Innovations in monoclonal antibody-based multipurpose prevention technology (MPT) for the prevention of sexually transmitted infections and unintended pregnancy. Front Reprod Health. 2024 Jan 9;5:1337479. doi: 10.3389/frph.2023.1337479. PMID: 38264184; PMCID: PMC10803587.
Dohadwala S, Politch JA, Barmine JH, Anderson DJ. A Brief History and Advancement of Contraceptive Multipurpose Prevention Technology (cMPT) Products. Open Access J Contracept. 2023 Jun 13;14:83-94. doi: 10.2147/OAJC.S375634. PMID: 37332341; PMCID: PMC10276588.
Baldeon-Vaca, G., Marathe, J. G., Politch, J. A., Mausser, E., Pudney, J., Doud, J., Nador, E., Zeitlin, L., Pauly, M., Moench, T. R., Brennan, M., Whaley, K. J., & Anderson, D. J. (2021). Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women. EBioMedicine, 69, 103478. https://doi.org/10.1016/j.ebiom.2021.103478
Deborah J. Anderson, Daniel S. Johnston, A brief history and future prospects of contraception. Science380,154-158(2023).DOI:10.1126/science.adf9341
Nador E, Mausser E, Marathe JG, Politch JA, Thurman AR, Whaley KJ, Anderson DJ. Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film. Fertil Steril. 2024 Oct 22:S0015-0282(24)02320-3. doi: 10.1016/j.fertnstert.2024.10.026. Epub ahead of print. PMID: 39447830.
Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel). 2024 Mar 6;13(1):17. doi: 10.3390/antib13010017. PMID: 38534207; PMCID: PMC10967333.
Dohadwala S, Geib MT, Politch JA, Anderson DJ. Innovations in monoclonal antibody-based multipurpose prevention technology (MPT) for the prevention of sexually transmitted infections and unintended pregnancy. Front Reprod Health. 2024 Jan 9;5:1337479. doi: 10.3389/frph.2023.1337479. PMID: 38264184; PMCID: PMC10803587.
Dohadwala S, Politch JA, Barmine JH, Anderson DJ. A Brief History and Advancement of Contraceptive Multipurpose Prevention Technology (cMPT) Products. Open Access J Contracept. 2023 Jun 13;14:83-94. doi: 10.2147/OAJC.S375634. PMID: 37332341; PMCID: PMC10276588.
Deborah Anderson In the News
- "A New Breed of Nonhormonal Birth Control" in Boston University's The Brink
- "Why We Need a Contraception Revolution" in Boston University's The Brink
- "Scientists are trying to create a contraceptive that stops sperm in its tracks" by STAT
Meet MCI's Grantees & Fellows!
Our grantees and fellows represent some of the finest minds in the male contraception research community from around the world.
At Male Contraceptive Initiative, we prioritize funding research that aligns with our mission of driving male contraception closer to clinical trials. We strategically allocate our resources to support a diverse range of projects, focusing on non-hormonal and reversible methods that have the potential to meet the needs of a broader population. Our goal is to catalyze progress in this field and bring innovative male birth control options to market.
Discover the innovative research being conducted by our grantees and fellows by clicking on the buttons below:
At Male Contraceptive Initiative, we prioritize funding research that aligns with our mission of driving male contraception closer to clinical trials. We strategically allocate our resources to support a diverse range of projects, focusing on non-hormonal and reversible methods that have the potential to meet the needs of a broader population. Our goal is to catalyze progress in this field and bring innovative male birth control options to market.
Discover the innovative research being conducted by our grantees and fellows by clicking on the buttons below:
Looking for Something?
Welcome to your comprehensive resource on the future of male contraception! We have packed this site with vital information, and to help you find exactly what you need, we've created a detailed guide. Please use the Table of Contents on our homepage to easily navigate to the research, news, or resources that interest you most. This will ensure you can explore all of our important content with ease. You can access the Table of Contents by clicking on the button below: