MCI Fellows are a mix of graduate and postdoctoral trainees, all working towards creating non-hormonal, reversible male contraceptive methods. Our support allows them to focus on the research, publish data, and build the background they need to sustain a long career as an investigator.
Oleksandr is a PhD candidate in the Geyer laboratory at the Brody School of Medicine at East Carolina University in Greenville, North Carolina. His work is focused on defining the mechanisms underlying spermatogonial differentiation and meiotic initiation. Using a novel transgenic mouse model, Oleksandr is isolating large pure populations of spermatogonia at each stage of their development and employing broad-based ‘omics technologies to define the transcriptome, translatome, and proteome during this understudied phase of male germ cell development. His goal is to identify specific molecular contraceptive targets for drug design in differentiating spermatogonia and preleptotene spermatocytes, which both reside outside the blood-testis-barrier. MCI’s support enables him to complete these exciting studies and prepare for a career in the reproductive sciences after graduate school.
Saman is a PhD candidate at University of Massachusetts Amherst in Dr. Pablo Visconti’s lab studying the role of testis specific serine kinases (TSSKs) on male fertility. TSSKs are kinases present in both germ cells and mature sperm, leading us to hypothesize that they are essential for sperm differentiation and maturation. MCI fellowship allows Saman to learn advance instrumental techniques along with impressive collaborations to target TSSKs as novel male contraceptives.
Noman is a PhD candidate in the Georg group at the University of Minnesota in the Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development. His research goal is to develop RARɑ antagonists as male contraceptive agents. RARɑ is a receptor for vitamin A metabolite - retinoic acid - and is essential for the production of sperm. Noman aims to block RARɑ signaling using drug-like small molecules to inhibit the sperm production. Support from MCI allows him to expand his work, learn new skills, and advance his career.
Melanie is a postdoctoral researcher at Weill Cornell in New York City working on soluble adenylyl cyclase (sAC), a protein essential for sperm motility and capacitation. Melanie is working across disciplines to develop an inhibitor of sAC that could be used as a contraceptive. MCI’s Fellowship Program allows her to collaborate with unique partnerships and gain new skills in drug development, all within the realm of male contraception.
Aaron was recently a postdoctoral researcher in Palo Alto, California working at Stanford University. His research was on HIPK4, a novel protein kinase expressed in the testes. Aaron is trying to understand the roles of HIPK4 in sperm development and function with the aim of understanding more about the protein as a target for contraception. MCI’s Fellowship Program not only allowed Aaron to focus on a contraceptive project, but allowed him to publish his work and move on to a career at Vibliome Therapeutics – continuing his contraceptive focus. Read more about Aaron’s work here.
As a graduate student at Berkeley, Liliya works in the Lishko Lab on sperm motility. Her project is seeking to develop ANT4 as a male contraceptive. ANT4 is involved in the transport of energy in mature sperm cells and is required for them to swim. Liliya’s work is looking for interesting ways of shutting down ANT4, and making spermatozoa nonmotile. With MCI’s support, Liliya has funding to grow her career and investigate an exciting project.
Jae Yeon is a postdoctoral researcher in the lab of Jean-Ju Chung at Yale. He’s working on CatSper, one of the most interesting, but stymieing contraceptive targets. CatSper is required for male fertility, but is difficult to study because of its complexity. Jae Yeon is developing a new screening platform that makes it easier to develop drugs for CatSper. With MCI’s support, he can push this target closer to the main stage.
Max is a graduate student in the lab of Celia Santi at WashU in St. Louis. His project is on SLO3, a protein in sperm required for capacitation and fertilization. In a collaborative project across institutions and fields, Max is testing inhibitors of SLO3 and making spermatozoa nonmotile. With MCI’s support, Max has the funding to focus on the science, publish his work, and build a career.
Interested in becoming an MCI Fellow? More information on our Funding page.