Developing non-hormonal, reversible contraception to provide options outside of vasectomy.
Male Contraceptive Initiative is dedicated to supporting the development of new, non-hormonal, reversible male birth control options. We provide funding and advocacy to researchers working diligently on this groundbreaking area of reproductive health.
Explore Your Options
Join us in advocating for expanded reproductive choices for men!
Explore Your Options
- Current Contraceptives: Learn about the limited options available for sperm-producers today.
- The Future of Male Contraception: Discover the promising research and development efforts underway to bring innovative new methods to market.
Join us in advocating for expanded reproductive choices for men!
Expanding Reproductive Choices: The Importance of Male Birth Control
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Family planning is essential for empowering individuals and couples to make informed decisions about the size and timing of their families. Unfortunately, the limited options available for male birth control have traditionally placed a disproportionate burden on women.
The Benefits of Expanding Male Birth Control Options:
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"Male Contraceptive Initiative Overview" Animated Video
MCI's Vision (click the image for more details)
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Empowering Couples: The Power of Male Contraception
Male Contraceptive Initiative is dedicated to expanding the range of contraceptive options available to men. By supporting the development of new, non-hormonal, reversible methods, we aim to:
Male Contraceptive Initiative is dedicated to expanding the range of contraceptive options available to men. By supporting the development of new, non-hormonal, reversible methods, we aim to:
- Empower men: Provide men with greater control over their reproductive health.
- Strengthen relationships: Foster stronger, healthier relationships based on equality and mutual understanding.
- Promote reproductive autonomy: Empower individuals and couples to make informed choices about family planning.
Traditional Male Contraceptive Options
Vasectomy
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Vasectomy is a safe and effective form of permanent male birth control. It involves a simple surgical procedure that prevents sperm from reaching the urethra, thus preventing fertilization.
Key Points:
If you're considering vasectomy, it's important to consult with a qualified healthcare professional to discuss the procedure, potential risks, and benefits, as well as any concerns you may have. |
"Existing Contraceptive Methods" Infographic
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Condoms
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Condoms are the only reversible, non-hormonal form of male contraception that also offers protection against sexually transmitted infections (STIs). They are barrier devices used during sexual intercourse to prevent pregnancy and STIs.
Key Benefits of Condoms:
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MCI's "Nuts & Bolts: 10 Facts About Vasectomy" Animated Video
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How to Use Condoms:
Where to Obtain Condoms: Condoms are available over-the-counter at drugstores, supermarkets, and family planning clinics. Public health organizations often distribute condoms for free to promote safer sex practices.
Remember: Consistent and correct use of condoms is crucial for achieving the desired level of protection against pregnancy and STIs.
- Proper application: Correct application and removal techniques are essential to prevent tears or slippage.
- Consistency: Use a condom during every act of intercourse for maximum effectiveness.
Where to Obtain Condoms: Condoms are available over-the-counter at drugstores, supermarkets, and family planning clinics. Public health organizations often distribute condoms for free to promote safer sex practices.
Remember: Consistent and correct use of condoms is crucial for achieving the desired level of protection against pregnancy and STIs.
Challenges & Limitations
Vasectomy
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While vasectomy offers reliable and permanent contraception, it's important to carefully consider the potential emotional and psychological consequences of this decision. Some individuals may experience feelings of regret or loss of reproductive options if their life circumstances change.
Misconceptions about vasectomy can also pose challenges. It's crucial to dispel myths and provide accurate information about the procedure, its impact on masculinity and sexual performance, and the potential for reversal. |
MCI's "Nuts & Bolts: Vasectomy" Animated Short
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Condoms
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MCI's "Nuts & Bolts: Condoms" Animated Short
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Condoms are widely accessible and effective, but they do have limitations:
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Informed Decision-making
It's important to weigh the benefits and drawbacks of each contraceptive option and make an informed decision based on individual needs and preferences. Consulting with a healthcare provider can help you understand the risks and benefits of vasectomy and condoms and choose the best option for you.
Expanding Reproductive Choices: The Need for Alternative Male Contraception
The landscape of reproductive health is evolving, and there is a growing demand for a wider range of male contraceptive options beyond vasectomy and condoms. These traditional methods have limitations that highlight the need for more flexible and accessible options for diverse populations.
The Benefits of Expanding Male Contraception:
By investing in the development of alternative male contraceptives, we can create a more equitable and inclusive reproductive health landscape.
The Benefits of Expanding Male Contraception:
- Challenging gender norms: Involving men more directly in family planning can challenge traditional gender roles and promote healthier relationships.
- Empowering couples: Expanding contraceptive choices allows couples to make joint decisions that align with their life stages, relationship dynamics, and desired family size.
- Improving physical and environmental health: Male contraception can contribute to better physical and environmental health outcomes, aligning with Sustainable Development Goals.
- Serving the LGBTQIA+ community: Providing accessible and effective male contraception options is essential for members of the LGBTQIA+ community.
By investing in the development of alternative male contraceptives, we can create a more equitable and inclusive reproductive health landscape.
Non-Hormonal Male Contraception: A Closer Look
Hormonal contraceptives work by influencing the endocrine system, the body's system of hormones that regulate various functions like mood, growth, metabolism, and reproduction. Disruptions to the endocrine system can impact fertility, which is why hormonal contraceptives can be effective.
Non-hormonal contraceptives, on the other hand, do not affect hormones. Common types include:
While non-hormonal methods often have fewer side effects than hormonal ones, some, like withdrawal and the rhythm method, have low effectiveness. It's important to choose a method that aligns with your individual needs and preferences!
Non-hormonal contraceptives, on the other hand, do not affect hormones. Common types include:
- Barrier methods: Condoms, diaphragms, and sponges physically prevent sperm from reaching the uterus.
- Copper IUDs: A small, T-shaped device inserted into the uterus to prevent pregnancy.
- Outercourse: Engaging in sexual acts without vaginal penetration.
- Withdrawal: Removing the penis before ejaculation.
- Sterilization: Permanent procedures like vasectomy for men or tubal ligation for women.
- Rhythm method: Tracking menstrual cycles to predict ovulation and avoid conception.
While non-hormonal methods often have fewer side effects than hormonal ones, some, like withdrawal and the rhythm method, have low effectiveness. It's important to choose a method that aligns with your individual needs and preferences!
"Hormonal vs Non-hormonal Contraceptives" Infographic
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MCI's "Nuts & Bolts: Hormonal vs. Non-hormonal Contraception" Animated Video
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Novel Non-Hormonal Contraception: A New Era
The development of non-hormonal contraceptives is revolutionizing the landscape of family planning. These innovative products offer men greater flexibility and choice, similar to hormonal options, without the associated drawbacks.
How Non-Hormonal Contraceptives Work:
How Non-Hormonal Contraceptives Work:
- Targeted approach: Unlike hormonal methods, non-hormonal contraceptives focus on inhibiting specific cellular activities involved in sperm production, transport, or function.
- Reduced side effects: This targeted approach minimizes the risk of "off-target" effects, resulting in fewer or no side effects.
Male Contraceptive Initiative's Focus
At Male Contraceptive Initiative, we're committed to providing men with reliable, safe, and reversible birth control options. Our focus on non-hormonal contraceptives aligns with our vision of reproductive autonomy for all.
Innovative Approaches:
At Male Contraceptive Initiative, we're committed to providing men with reliable, safe, and reversible birth control options. Our focus on non-hormonal contraceptives aligns with our vision of reproductive autonomy for all.
Innovative Approaches:
- Disrupting sperm production: Targeting the process of spermatogenesis.
- Impairing sperm motility: Interfering with the ability of sperm to move.
- Blocking sperm transport: Preventing sperm from reaching the urethra.
- Altering sperm function: Affecting the sperm's ability to fertilize an egg.
These pioneering mechanisms hold immense potential for transforming family planning by offering effective, reversible male contraception without hormonal side effects.
Progress & Research
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MCI is committed to furthering the research and development of non-hormonal, reversible male contraceptive options, and offer support through scientific granting to a diverse portfolio of researchers. Our grantees work from the basic science all the way through the drug development pipeline to clinical trials to make the next generation of non-hormonal, reversible male birth control a reality.
MCI provides funding and advocacy support for myriad different potential male contraceptives in order to ensure that a robust method mix is in development every step of the way. Through these efforts, we hope to ensure that the individual needs and interests of men and couples are catered to in order to ensure early adoption and continued use of these critically important, yet currently missing, family planning tools. These alternatives to condoms and vasectomy that researchers are working on now, include varied and diverse options. |
"Vasectomy Alternatives & Next Generation Male Contraception" Infographic
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What are the male birth control research activities MCI is supporting?
The science of male birth control can be a little intimidating if you do not have a background in science. To counter this, we created this section to make the work we are supporting a bit more accessible to the general public.
A single injection that ensures a man cannot cause a pregnancy for years and is completely reversible.
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Our grantee Contraline has invented a proprietary hydrogel called ADAM™ that is implanted into the vas deferens through a minimally invasive, outpatient procedure.
The hydrogel works by blocking sperm from traveling through the vas deferens. Similar to intrauterine devices (IUDs) for women, Contraline’s contraceptive is designed to last for years and be reversible. MCI’s support will be used by Contraline to prepare for filing with the FDA and initiating first-in-human trials. |
A reversible male birth control that impacts the head of the sperm, preventing it from fertilizing an egg.
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Our grantee Dr. Wei Yan and his team of researchers have developed a new compound derived from a Chinese herb called the Thunder God vine (Tripterygium Wilfordii Hook F).
The compound works by causing the head of sperm to be malformed such that they are not able to connect with and fertilize a female egg. This effect only occurs while the compound is consumed, and normal function is fully restored after discontinuing use. MCI’s support allowed Dr. Yan and his team to explore the effects of the compound and publish their results. Because of MCI’s grant, our sister organization Contraceptive Accelerator Network is performing nonclinical studies on Triptonide that advance it towards human studies. |
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Our grantee Dr. Mario Buffone has been working in the field of sperm physiology for two decades. His lab seeks to understand the complex process of mammalian sperm capacitation, the change sperm undergo in the female reproductive tract that enables them to penetrate and fertilize an egg.
Dr. Buffone is working to screen and identify drugs that are able to prevent the capacitation and therefore render sperm incapable of fertilizing an egg. MCI is supporting the Buffone lab’s studies with the intent of moving towards in vivo preclinical studies. |
A biodegradable implant injected just below the skin’s surface that can deliver a male contraceptive over a sustained period of time.
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Our grantee Dr. Rahima Benhabbour designs and fabricates delivery platforms for HIV prevention, cancer treatment, and contraception.
Dr. Benhabbour launched her first start-up AnelleO, Inc. in 2016, focusing on developing 3D-printed intravaginal rings for the treatment of infertility. MCI’s support will help facilitate studies that develop and implement an injectable device that can carry drug and translate into human studies. |
A daily, or even on-demand, method of male birth control that prevent sperm from being able to swim when taken.
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Our grantee Dr. Gunda Georg’s group has published over 200 scientific articles on the design, synthesis, and evaluation of biologically active agents. In addition to male contraception, her lab investigates areas of cancer and female contraception.
Dr. Georg's lab has focused on investigating the testis-specific serine kinase (TSSK) family. These proteins are expressed after sperm have been developed, and are likely involved in multiple steps that could make them excellent contraceptive targets. MCI’s support will help Dr. Georg’s team investigate the sperm-specific isoform of Na,K-ATPase, which is crucial for sperm motility (e.g., sperm’s ability to swim). |
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Our grantee Dr. Mike O’Rand is the President and Chief Scientific Officer of Eppin Pharma, named after the protein EPPIN which is a critical component of sperm development.
Dr. O’Rand is developing a compound called EP055, a small organic compound that that targets EPPIN on the surface of sperm and prevents sperm from swimming. MCI’s support will help support Dr. O’Rand Investigational New Drug (IND)-enabling milestones that are required for Eppin Pharma to begin the process of entering first-in-man studies for EP055. |
A reversible male birth control method that causes sperm to become sterile.
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Our grantee Dr. Stephen L’Hernault and his lab have worked on spermatogenesis (i.e., sperm creation) and fertilization for over 30 years.
Dr. L’Hernault is working on developing compounds that can block the function of the IZUMO1 protein, which is required to fertilize an egg. MCI’s support will help Dr. L’Hernault’s team to identify small compounds that reversibly block the function of the IZUMO1 protein. |
A cohort of excited young researchers motivated by curiosity, ambition, and the social good associated with male birth control.
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Our Fellowship program features a mix of graduate and postdoctoral trainees, all working towards creating non-hormonal, reversible male contraceptive methods.
Our Fellows work on a diverse portfolio of projects that help move the male birth control forward. Our support allows our distinguished Fellows to focus on the research, publish data, and build the background they need to sustain a long career as an investigator. |
An on-demand method of male birth control that you take just before sex.
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Drs. Lonny Levin and Jochen Buck are professors at Weill Cornell Medicine and are working on inhibitors of soluble adenylyl cyclase (sAC) as on-demand male contraceptives. Their deep expertise in sAC keeps them attuned to the effects of inhibitors on sperm functions such as motility.
MCI is supporting work that develops novel inhibitors of sAC as on-demand male contraceptives as well as translational research that assesses the pharmacodynamics of inhibitors on human sperm. These steps are crucial to understanding how the drug stays associated to sperm after ejaculation and its potential contraceptive efficacy. |
Get Involved
Your support is vital to advancing male contraceptive research and empowering reproductive autonomy for all. There are several impactful ways you can make a difference:
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Spread Awareness
You can play a significant role through advocacy efforts. Start conversations with friends or family about the importance of shared family planning responsibility. Share our webpage, infographics, videos, or other resources among your networks to educate others. |
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Volunteer
As a small team, we welcome volunteers who are passionate about driving change. You might be interested in joining one of our youth initiatives, or taking a survey to share your perspective on male birth control. If you're interested in lending your skills, time, or expertise, please contact us! |
Your contribution, whether through donations, spreading awareness, or volunteering, strengthens our collective efforts to reshape family planning and create a future where diverse male contraceptive options are accessible to all. Join us in advocating for reproductive autonomy and playing a role in shaping a more inclusive and equitable world.
MCI's "Advocating for Male Contraception" Animated Video