Zhibing Zhang, Associate Professor
$150,000 / 2 years
Zhibing Zhang, PhD
Wayne State University
Dr. Zhibing Zhang is an Associate Professor in the Department of Physiology at Wayne State University. He also holds a joint appointment at Department of Obstetrics/Gynecology. He has been working in the field of sperm motility and spermatogenesis, particularly spermiogenesis, for almost two decades.
MCI is supporting the Zhang lab to study the meiosis expressed gene 1(MEIG1)/Parkin co-regulated gene(PACRG) complex, which is present in the manchette of elongating spermatids. The manchette is a transient microtubule-containing structure present only in elongating spermatids. One proposed function of the manchette is to transport cargo proteins for sperm flagella assembly by intra-manchette transport (IMT). Global disruption of Meig1 in mice results in severely defective spermiogenesis and failure of flagellogenesis. As such, MEIG1 is an excellent target for the development of male-based contraceptive drugs by blocking interactions of MEIG1/PACRG.
MCI will support Dr. Zhang and his lab to optimize a cell-free luciferase assay to identify small molecule inhibitors of MEIG1/PACRG interaction. These small molecule inhibitors have potential for the development of male-based contraceptives.