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The Mechanisms of Male Contraception

A halved pomegranate sits on a plain surface, while several brown seeds with thin black tails are arranged below, resembling sperm swimming toward the fruit.

There is more than one way to contracept.

Exploring the landscape of male contraception reveals multiple biological targets for reversible inhibition of fertility, each leading to contraceptives with unique profiles. To facilitate a deeper understanding of these targets and their potential, this page offers links to comprehensive primers that illustrate both the target categories and the prospective functional mechanisms of related contraceptives.

Spermatogenesis

Spermatogenesis is the creation of mature sperm from germ cells, and presents unique opportunities with respect to male methods of contraception. This primer provides more details.

Nuts & Bolts: Spermatogenesis

Sperm Transport

Preventing sperm from being transported out of the reproductive tract is the basis of vasectomy, one of the only existing forms of male contraception, and the ability to reversibly block ​this process represents huge potential for new, additional male contraceptives.

Nuts & Bolts: Sperm Transport

Sperm Motility

One key feature of sperm is their ability to swim through the reproductive tract. This ability, or sperm motility, is one of the most exciting targets of male contraception. This prime provides additional details.

Nuts & Bolts: Sperm Motility

Fertilization

Fertilization is the joining of human egg and sperm to create a zygote, and is a prime target for male contraception because of its place as the last step in the reproductive chain. Learn more in this primer.

Nuts & Bolts: Fertilization

Need more?

Are there any additional primers that would be useful to you? Please reach out to us and let us know what you are looking for!